Extra n-Heksana Antifungi Cream Alpinia Galanga

Abstract

The use of galangal in the community is a common thing, in addition to cooking, it is used also to treat skin diseases caused by fungi, but the application is still traditional. Besides, many studies report that the compound in ginger have activity as an antifungal, among others, Trichophyton metagrophytes that causes ringworm. One of the elucidations showed that the galangal ethanol extract was able to treat the rabbits’ skin affected by the fungus, but its ability was less than the active antifungal cream compound on the market, katenazol. Other studies have shown that ginger nonpolar extract effectively inhibits the growth of fungi T metagrophytes, but it has not been applied in the form of cream, nor there has a report on the impact of galangal extract allergy cream. The study traces the nonpolar extract of galangal against Trichophyton metagrophytes, compared with katenazol, applied in the form of creams, and skin allergy test. Based on the search results, the minimum inhibitory diameter of the ringworm fungus, between the galangal n-hexane extract has a greater value than the positive control, which is 36 mm. Spot on TLC between galangal nonpolar extract have the same Rf as katenazol, 0,62, and this extract does not affect skin allergy after 2 hours of use. The result of this study is expected to improve the utilization of galangal as an antifungal in the form of cream.