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ABSTRACT:
In literature, wild mushrooms are used extensively all over the world and considered them as more valuable food in terms of low calories and fat content. The objective of our study is to evaluate its antioxidant, anti-inflammatory and antimicrobial potential of protein extracted from two different species of mushroom (Oyster and button). The major parameter is to determine its anti-inflammatory (using Typhoid vaccine) and antioxidant (using DPPH assay) between treatment group of protein content (10-1000pg) from mushroom and control group. In addition, we also measured its phenolic content and also determining its denaturation assay using ovalbumin. The results of these studies which showed the presence of protein content is more in case of button mushroom as compared to oyster mushroom whereas higher phenolic content in oyster mushroom. In addition, both species of protein content using variable concentration extracted from mushroom stimulated with typhoid vaccine (25 pg/ml; 10pl) showed anti-inflammatory potential at higher doses as compared to control. Typhoid vaccine used as standard for these studies and showed stimulation as compared to control. In contrast, oyster mushroom showed less protein denaturation (using ovalbumin as standard) as compared to button mushroom and standard drug. Overall, protein from mushroom species showed antioxidant, anti-inflammatory and antimicrobial potential as well.
KEYWORDS: Mushroom, antioxidant, antimicrobial, anti-inflammatory, typhoid.
INTRODUCTION:
Mushrooms are considered to be one of the most health promoting foods because of its nutritional value and rich source of fibre (beta-glucans and chitin) and protein [1, 2]. In addition, it may contained most essential nutrients e.g. vitamins, selenium, potassium, copper etc. Interestingly, humans are more closely associated with fungi group because of its essential molecules that are reported in human diet [1-4]. As per the literature, nutritional and medicinal value or source of mushroom is mainly affected through various factors i.e. species, type of variety including its developmental stage along with environmental conditions [4-7].
In contrast, specific bioactive compounds (polysaccharides, low molecular weight proteins, glycoproteins etc.) are also reported in medicinal mushrooms and showing diverse medicinal properties [1-7]. The most familiar example in case of drugs extracted from mushrooms which may be helpful in the treatment of cancer, diabetics, high cholesterol, depression etc. In short, different varieties of mushroom are available and showed its economic importance as well and...