Content area
Full Text
ABSTRACT:
Aspirin tablet is prepared by wet granulation method. Aspirin belonging to the class of NSAID having analgesic, antipyretic, anti-inflammatory and antiplatelet activity at systematic standard doses. In this Lubricants in combination leads to better drug release kinetic. The Prepared Tablet is Evaluated In terms of bulk density, tapped density, the angle of repose, Carr's Index and, hardness test, weight variation test, friability test and in vitro study. The result associated with optimized batch is good satisfactory and having better drug release kinetic. The in-vitro dissolution studies we got result our formulation follow Zero Order Kinetics with the effect of lubricants using in combination for better kinetic drug release.
KEYWORDS: Aspirin, Wet granulation compression method and Release Kinetic.
INTRODUCTION:
Aspirin also has an antiplatelet effect by inhibiting the creation of thromboxane, which binds platelet molecules together to generate a patch over damaged walls of blood vessels. Aspirin is used for long-term, at low doses, to prevent heart attacks. Aspirin tablets are obtained by wet Compression Method. The particles to be compressed consist of one or more medicaments, with or without excipients substance such as diluents, binders, and disintegration agents, lubricant, glidants and substances capable of modifying the behavior of the medicaments in the digestive tracts. Such substances must be innocuous and therapeutically inert in the quantities present.
Many strategies are available for the design and development of modified-release drug delivery formulations. [1]
Conventional oral dosage forms often produce fluctuations of drug plasma level that either exceeds safe therapeutic level or quickly fall below the minimum effective level; this effect is usually totally dependent on the agent's biologic half-life, the frequency of administration, and especially the releaserate[2]. For this purpose, aspirin which is analgesic and antipyretic was selected as a model drug. They are intended for oral administration. Some tablets are swallowed whole or after being chewed, some are dissolved or dispersion in water before administration and some are retained in the mouth where the active ingredient is liberated. Preparation intended for administration by other routes, for example, in the form of implants and passerines may also be presented in the form of tablets but because they may require special formulations, methods of manufacture or from of presentation appropriate to the use they may not...