Content area
Full Text
ABSTRACT:
Chronotherapeutic delivery system is required to be formulated to suit drug release conditions in various diseases like cardiovascular diseases, asthma etc. Asthma is disease of lung airways (bronchi) characterized by hyper active responsiveness to a variety of stimuli. Nocturnal asthma is condition where an exacerbation of the asthma is observed during the night times, such that worsening the functioning of the lung with increased airway response. Usually, asthma attacks are more predominant in early mornings so it is annoying for a patient to take medicine at late night, hence in this condition there is a demand for pulsatile drug delivery system which release the drug at required time at proper site with efficient therapeutic action. The main advantage of releasing the drug in required time in required quantity with satisfactory lag time. In the present study the doxofylline tablet was prepared by direct compression method and tablets were coated by dip coating method by using Sodium Starch Glycolate, Microcrystalline cellulose, Eudragit S100, Ethanol, Isopropyl alcohol, Dibutylpthalate. The tablets prepared were evaluated for various parameters like density parameters, thickness, hardness, friability, disintegration time, dissolution time. All parameters were found to be within limits. It was concluded that Formulation F6 was the ideal formulation with lag time of 6 hrs followed by burst release of drug.
KEYWORDS: Doxofylline, Microcrystalline cellulose, Sodium Starch Glycolate, Isopropyl alcohol, Eudragit (S-100).
(ProQuest: ... denotes formulae omitted.)
1.INTRODUCTION:
Chronotherapeutics discusses about the treatment method where the in vivo drug release is programmed to match the rhythms of disease such that to obtain the required therapeutic outcomes and abate side effects[1,2]. 1-4 Circadian rhythms are self-sustaining, endogenous oscillations that occur with a periodicity of about 24 hours and are synchronized according to internal biologic clocks related to the sleep-wake cycle. The bestknown circadian rhythms include body temperature, hormone secretion, metabolism, sleep or wake cycle[3,4]. Chronotherapeutic delivery system is required to be formulated to suit drug release conditions in various diseases like cardiovascular diseases. Asthma is disease of lung airways (bronchi) characterized by hyper active responsiveness to a variety of stimuli and in this condition the airways constricts and becomes inflamed with excess mucus lining the passage.
The stimuli which may trigger the asthmatic condition includes exposure to allergens, cold air, moist...