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ABSTRACT:
Fast dissolving dosage forms have acquired great importance in pharmaceutical industry because of their unique properties like dissolve upon contact with a wet surface, such as the tongue, within a few seconds, meaning the consumer can take the product without need for additional liquid. This convenience provides both a marketing advantage and patient compliance. The present study aimed at preparing fast dissolving oral films of Promethazine Hydrochloride oral fast dissolving films that offers a suitable approach for the treatment and management of nausea and vomiting. In the present investigation different types of polymer like HPMC, HPC, polyvinyl pyrolidone, aspartame, poly vinyl alcohol to prepare quick films. The prepared films were evaluated for film thickness, folding endurance, surface pH, morphological properties, % drug content and content uniformity, tensile strength, percent elongation, in vitro disintegration time and in vitro dissolution studies.
The physical appearance was found to be good and shows that films were transparent physical appearance was found to be good and shows that films were transparent with smooth surface without any scratches. The folding endurance was showed that films have good flexibility. In-vitro drug release for Promethazine of all the formulations showed 60-90% within four minutes.
KEYWORDS: Quick dissolving films, Promethazine Hydrochloride, Solvent casting, Poly vinyl alcohol, Poly vinyl pyrolidone, HPMC, HPC, Aspartame.
INTRODUCTION:
Oral route is the most preferred route of administration of drugs because of accurate dosage, self medication, low cost and ease of administration leading to high level of patient compliance. The buccal cavity is an attractive route of administration for Systemic drug delivery. Oral mucosa has a rich vascularization and offers higher permeability to many drugs. It has been well known that after buccal and sublingual administration drug solutes are rapidly absorbed in to the reticulated vein and are then drained into the systemic circulation1,3,4.
The concept of Fast Dissolving Drug Delivery System emerged from the desire to provide patient with a conventional mean of taking their medication. Difficulty in swallowing (Dysphagia) is a common problem of all age groups, especially elderly and paediatrics, because of physiological changes associated with these groups of patients. Recently Various bio-adhesive and mucosal dosage forms have been formulated which includes adhesive tablets, gels, ointments, patches and more recently the mouth disintegrating films have...