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Web End = Neurol Sci (2015) 36:961969 DOI 10.1007/s10072-015-2205-2
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Web End = Gender-specic effects of CGP 55845, GABAB receptor antagonist, on neuromuscular coordination, learning and memory formation in albino mouse following neonatal hypoxiaischemia insult
Quratul Ane Gillani1,3 Atif Akbar2,3 Muhammad Ali2,3 Furhan Iqbal1,3
Received: 25 August 2014 / Accepted: 1 April 2015 / Published online: 7 April 2015 Springer-Verlag Italia 2015
Abstract GABAB receptor antagonists are experimentally proved as spatial memory enhancers in mouse models but their role has not been described following hypoxic ischemic insult. 10-day-old albino mice were subjected to Murine model of hypoxia and ischemia. Following brain damage, mice were fed on normal rodent diet till they were 13 weeks old. At this time point, mice were divided into two groups. Group 1 received saline and group 2 received intraperitoneally CGP 55845 (1 mg/ml solvent/Kg body weight) for 12 days. Behavioural observations were made during rota rod, open eld and Morris water maze test along with brain infarct measurement in both CGP 55845 treated and untreated groups. It was observed that application of GABAB receptor antagonist improved the over all motor function in male and female albino mice but effects were more pronounced in males. In open eld, CGP 55845-treated female mice showed poor performance. CGP 55845 had no signicant effect on learning and memory formation during Morris water maze test and also on brain infract size in both genders following hypoxia ischemia encephalopathy. Effects of CGP 55845 can be further explored in a dose and duration dependent manner to improve the learning and memory in albino mice following neonatal brain damage.
Keywords CGP 55845 Hypoxia ischemia insult
Albino mice Morris water maze Brain infract
Introduction
During gestation or delivery, the accidental asphyxia of infants or perinatal hypoxiaischemia (HI) is a common cause of neurological decits and delayed cognitive and behavioral decits [1]. Hypoxiaischemia disrupts selected regions at different ages of the immature brain especially prenatal/neonatal stages [2].
GABAB receptors are heterodimeric G protein-coupled sites. GABAB are located both pre- and postsynaptically [3]. GABAB receptor antagonist...