Content area
Abstract
We present a consolidated view of the complexity and challenges of designing studies for measurement of energy metabolism in mouse models, including a practical guide to the assessment of energy expenditure, energy intake and body composition and statistical analysis thereof. We hope this guide will facilitate comparisons across studies and minimize spurious interpretations of data. We recommend that division of energy expenditure data by either body weight or lean body weight and that presentation of group effects as histograms should be replaced by plotting individual data and analyzing both group and body-composition effects using analysis of covariance (ANCOVA). [PUBLICATION ABSTRACT]
Details
Title
A guide to analysis of mouse energy metabolism
Author
Tschöp, Matthias H; Speakman, John R; Arch, Jonathan R S; Auwerx, Johan; Brüning, Jens C; Chan, Lawrence; Eckel, Robert H; Farese, Robert V; Galgani, Jose E; Hambly, Catherine; Herman, Mark A; Horvath, Tamas L; Kahn, Barbara B; Kozma, Sara C; Maratos-flier, Eleftheria; Müller, Timo D; Münzberg, Heike; Pfluger, Paul T; Plum, Leona; Reitman, Marc L; Rahmouni, Kamal; Shulman, Gerald I; Thomas, George; Kahn, C Ronald; Ravussin, Eric
Pages
57-63
Publication year
2012
Publication date
Jan 2012
ISSN
15487091
e-ISSN
15487105
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1010624755
Copyright
Copyright Nature Publishing Group Jan 2012