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Web End = Mamm Genome (2015) 26:314324 DOI 10.1007/s00335-015-9563-1
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Web End = GXD: a community resource of mouse Gene Expression Data
Constance M. Smith1 Jacqueline H. Finger1 Terry F. Hayamizu1
Ingeborg J. McCright1 Jingxia Xu1 Janan T. Eppig1 James A. Kadin1
Joel E. Richardson1 Martin Ringwald1
Received: 20 March 2015 / Accepted: 13 April 2015 / Published online: 5 May 2015 The Author(s) 2015. This article is published with open access at Springerlink.com
Abstract The Gene Expression Database (GXD) is an extensive, easily searchable, and freely available database of mouse gene expression information (http://www.informatics.jax.org/expression.shtml
Web End =www.informatics. http://www.informatics.jax.org/expression.shtml
Web End =jax.org/expression.shtml ). GXD was developed to foster progress toward understanding the molecular basis of human development and disease. GXD contains information about when and where genes are expressed in different tissues in the mouse, especially during the embryonic period. GXD collects different types of expression data from wild-type and mutant mice, including RNA in situ hybridization, immunohistochemistry, RT-PCR, and northern and western blot results. The GXD curators read the scientic literature and enter the expression data from those papers into the database. GXD also acquires expression data directly from researchers, including groups doing large-scale expression studies. GXD currently contains nearly 1.5 million expression results for over 13,900 genes. In addition, it has over 265,000 images of expression data, allowing users to retrieve the primary data and interpret it themselves. By being an integral part of the larger Mouse Genome Informatics (MGI) resource, GXDs expression data are combined with other genetic, functional, phenotypic, and disease-oriented data. This allows GXD to provide tools for researchers to evaluate expression data in the larger context, search by a wide variety of biologically and biomedically relevant parameters, and discover new data connections to help in the design of new experiments. Thus, GXD can provide researchers with critical insights into the functions of genes and the molecular mechanisms of development, differentiation, and disease.
Introduction
Recent technological advances have made it possible to rapidly determine the sequences of individual human genomes and to correlate genetic mutations with human...