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ABSTRACT:
The present study is to evaluate the hepatoprotective effects of the 50% hydro-ethanol (Heena) extracts of stem bark of Nyctanthes arbor-tristis linn, against paracetamol induced hepatotoxicity in rats. The hepatoprotective effects of HEENA (500 mg/kg) was estimated by liver function test and serum profile. The results revealed that the extract of selected plant produce significant hepatoprotective effect not only by decreasing serum transaminase (SGPT and SGOT), alkaline phosphate and total bilirubin, but also significantly increased the levels of serum proteins (albumin, fibrinogen haeptoglobin, ceruloplasin, transferring etc). The effects of Heena was comparable with standard drug silymarin.
KEYWORDS: Hepatotoxicity; Nyctanthes arbor-tristis linn; Heena; SGPT; SGOT.
Received on 13.07.2015 Modified on 25.07.2015
Accepted on 05.08.2015 ©A&V Publications All right reserved
Res. J. Pharmacology & P'dynamics. 7(3): July-Sept., 2015; Page 124-128
INTRODUCTION:
The liver has an enormous task of maintaining the body's metabolic homeostasis. This includes, the processing of dietary amino acids, carbohydrates, lipids, and vitamins; synthesis of serum proteins; and detoxification and excretion into bile of endogenous waste products and pollutant xenobiotics. In addition, human beings consume a lot of synthetic drugs during diseased conditions which are alien to body organs. All these compounds produce a variety of toxic manifestations (Athar et al., 1997). The use of natural remedies for the treatment of liver diseases has a long history, starting with the Ayurvedic treatment, and extending to the Chinese, European and other systems of traditional medicines. The 21st century has seen a paradigm shift towards therapeutic evaluation of herbal products in liver disease. A large number of plants and formulations have been claimed to have hepatoprotective activity. Nearly 160 phytoconstituents from 101 plants have been claimed to possess liver protecting activity.
In India, more than 87 plants are used in33 patented and proprietary multi ingredient plant formulations. (Handa et al., 1986). India is well known for a plethora of medicinal plants. The medicinal use of many plants (as hepatoprotectants) like Flacourtia indica (Marina et al., 2009), Annona squamosa (Saleem et al., 2008), Silybum marianum and Cichorium intybus (Madani et al., 2008), Aegle marmelos (Vinodhini et al., 2007). Sida veronicaefolia (Sharma et al., 2012) has already been reported in literature. Nyctanthes arbor-tristis 'a night flowering sad tree' of family Oleaceae (nyctaginaceae) is well known in...