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population and impair brain development3. A better understanding of how centrosome cycle fidelity prevents these pathologies will require yet more pieces of the centriole disengagement puzzle to be put in place.
COMPETING FINANCIAL INTERESTS
The author declares no competing financial interests.
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Hippo signalling directs intestinal fate
Marie Le Bouteiller and Kim B. Jensen
Hippo signalling has been associated with many important tissue functions including the regulation of organ size. In the intestinal epithelium differing functions have been proposed for the effectors of Hippo signalling, YAP and TAZ1. These are now shown to have a dual role in the intestinal epithelium, regulating both stem cell proliferation and differentiation along a specific secretory lineage.
The intestinal epithelium requires constant replenishment to maintain its digestive and absorptive functions. The epithelium is composed of a single cell layer facing the lumen of the intestine and is organized into crypt-villus units composed of proliferative and post-mitotic differentiated cells. Intestinal stem cells (ISC) are located at the bottom of crypts and ensure maintenance of the tissue. Homeostasis is governed by tightly regulated proliferation and differentiation in the stem cell compartment, and their misregulation is associated with the development of cancers. Insights into...