Histopathological study of Cinnamomum zeylanicum equeous extract and Cladosporium sp. Extract on different albino male mice organs

Abstract

The objective of this study was to considered as an explorer for In vivo studies on the production of some secondary metabolites from local medical plants named Cinnamomum zeylanicum to study their effect on mice organs that treated with Cladosporium sp. extract (In vivo). Preparation of water extract of Cinnamomum zeylanicum. different doses were prepared (20,40,60,80%) of plant which (9) male mice were used and divided into three control group and dosed with distilled water mice were administrated with first dose 1ml/kg of Cladosporium extract for two weeks and mice were administrated Cladosporium with 80% of the aqueous extract of Cinnamomum zeylanicum at a dose of 1 ml / kg daily for two weeks. Mice treated with Cladosporium sp. fungal filtrate caused vascular congestion in the tissues of the liver resulting in cell bleeding, in addition to many changes in chromotin in and nuclei sized increased while the results indicate the ability of the mixture between fungal filtrate and Cinnamomum to counteract these adverse effect in mice and return its appearance looks like normal also the kidney of animals treated with Cladosporium fungal filtrate caused retention of congested glomeruli with a large pool of fluids while the result of interaction caused inhibition in radial growth of the fungus and reduced its effectiveness on kidney function and the synthetic form of the tissue.