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Abstract
Abdominal films in all patients showed definite sacroiliitis in three, all of whom were B27-positive and none of whom had clinical evidence of ankylosing spondylitis. [...]provided that our results are confirmed in other patients, colorectal cancer may join the group of diseases associated with HLA-B27. Since some microbial species (e.g., klebsiella) are thought to have a responsibility in the genesis of ankylosing spondylitis,5 and since some others (Streptococcus faecalis and clostridia) are thought to be colonic carcinogens,6, 7 it is conceivable that B27 antigen favors some intestinal dysmicrobisms that would lead to different specific diseases. [...]it is noteworthy that another potential colonic carcinogen, asbestos,8 can give rise to another B27-associated disease, asbestosis.9 1.