Content area

Abstract

Background

This study sought to determine the proportion of individuals with non-HIV secondary immunodeficiencies presenting inadequate antibody titers after rabies post-exposure prophylaxis (PEP) and to identify variables associated with inadequate response.

Methods

A retrospective review of the records of immunocompromised patients having received a full course of PEP after a rabies exposure and having been tested for post-PPE antibody titers in two French Antirabies Clinics, between 2013 and 2018, was conducted. Antibody titers < 0.5 EU/ml (ELISA) were classified as inadequate.

Results

A total of 28 individuals were included, 6 had inadequate post-PPE titers. None of the tested variable was independently associated with inadequate titers.

Conclusions

Inadequate response was unpredictable and not explained either by the characteristics of patients or by the PEP regimen they received. These findings support the WHO recommendation to systematically assess post-PEP response in immunocompromised patients to detect non-responders, who might require an additional dose.

Details

Title
Immune response to rabies post-exposure prophylaxis in patients with non-HIV secondary immunodeficiencies
Author
Parize, Perrine; Poujol, Philippe; Pascale Morineau Le Houssine; Goesch, Julia; Lucet, Cora; Basuyau, Laura; Cailhol, Johann; Dacheux, Laurent; Bourhy, Hervé; Paul-Henri Consigny
Pages
5091-5094
Section
Short communication
Publication year
2020
Publication date
Jul 14, 2020
Publisher
Elsevier Limited
ISSN
0264410X
e-ISSN
18732518
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2417873581
Copyright
©2020. Elsevier Ltd