Improvement of Synthetic Method of Lysine Aspirin

Abstract

The synthesis method of lysine aspirin was improved, and the new method was applied to the synthesis of similar new drugs. Aspirin is reacted with an aqueous solution of sodium hydrogen carbonate to prepare its sodium salt, and lysine was reacted with a sodium salt thereof in water to prepare lysine aspirin. The product was identified by melting point, infrared spectroscopy and high performance liquid chromatography; the cysteine salts of aspirin was prepared by this method, and the product was identified by micro melting point apparatus and infrared spectroscopy. Lysine aspirin was synthesized by the reaction of sodium acetylsalicylate with lysine. The author measured the melting point and infrared absorption spectrum of the cysteine salt sample of aspirin, which was initially determined to be possible. The new method offers the possibility to expand the production route of lysine aspirin, and also provides new ideas for the preparation of similar new drugs.