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Osteoporos Int (2013) 24:11691175 DOI 10.1007/s00198-012-2141-4
ORIGINAL ARTICLE
Increased risk of osteoporosis-related fractures in patients with irritable bowel syndrome
D. J. Stobaugh & P. Deepak & E. D. Ehrenpreis
Received: 13 June 2012 /Accepted: 1 August 2012 /Published online: 20 September 2012 # International Osteoporosis Foundation and National Osteoporosis Foundation 2012
AbstractSummary We sought to determine whether patients with irritable bowel syndrome (IBS) have an increased risk of osteoporosis and related fractures using the Nationwide Emergency Department Sample (NEDS). Patients with IBS had increased adjusted odds of osteoporosis and osteoporotic fractures compared to the non-IBS control group, controlling for known risk factors for osteoporosis. Screening measures to identify osteoporosis in this group are advised.
Introduction Ulcerative colitis, Crohns disease, and celiac disease have well-described augmented risk of osteoporosis and related fractures. We sought to determine whether IBS also indicates an increased risk of osteoporosis and related fractures. Methods The 2008 NEDS database was used to determine the adjusted odds of osteoporosis and related fractures in IBS patients. Only fractures (pathologic wrist (733.12), vertebrae (733.13), and femur fractures (733.14), traumatic wrist (813.x), vertebrae (805.x806.x), and hip fractures (820.x 821.x)) with a secondary diagnosis of osteoporosis (733.0x) were included in the analysis. A multivariate logistic regression analysis was performed, controlling for known risk factors for osteoporosis and related fractures.
Results We identified 317,857 ED visits in patients with a diagnosis of IBS. Of these, 17,752 carried a diagnosis of osteoporosis and 694 IBS patients had a concurrent diagnosis of a pathologic fracture of the wrist, hip, or vertebrae. A total of 1,503 IBS patients had a concurrent diagnosis of a traumatic fracture of the wrist, hip, or vertebra. Overall, patients with IBS had an increased adjusted odds of osteoporosis (odds ratio (OR) 4.28, 95 % confidence interval (CI)4.214.35) and osteoporotic fractures (OR 2.36, CI 2.262.47) compared to the non-IBS control group. The highest adjusted odds of fracture was seen at the wrist (OR 2.41, CI2.102.77 compared to controls).
Conclusions IBS patients are at an increased risk of osteoporosis and related fractures. Screening measures to identify osteoporosis and prevent fractures are advised.
Keywords Bone mineral density . Irritable bowel syndrome . Osteoporosis . Osteoporotic fractures
Introduction
Osteoporosis is a condition characterized by a reduction in bone mass, disruption...