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Mamm Genome (2012) 23:611622 DOI 10.1007/s00335-012-9415-1
Innovations in phenotyping of mouse models in the German Mouse Clinic
Helmut Fuchs Valrie Gailus-Durner Susanne Neschen Thure Adler Luciana Caminha Afonso
Juan Antonio Aguilar-Pimentel Lore Becker Alexander Bohla Julia Calzada-Wack Christian Cohrs
Anna Dewert Barbara Fridrich Lillian Garrett Lisa Glasl Alexander Gtz Wolfgang Hans
Sabine M. Hlter Marion Horsch Anja Hurt Eva Janas Dirk Janik Melanie Kahle Martin Kistler
Tanja Klein-Rodewald Christoph Lengger Tonia Ludwig Holger Maier Susan Marschall
Kateryna Micklich Gabriele Mller Beatrix Naton Cornelia Prehn Oliver Puk Ildik Rcz
Michael Ra Birgit Rathkolb Jan Rozman Markus Scheerer Evelyn Schiller Anja Schrewe
Ralph Steinkamp Claudia Stger Minxuan Sun Wilfried Szymczak Irina Treise Ingrid Liliana Vargas Panesso Alexandra M. Vernaleken Monja Willershauser Annemarie Wolff-Muscate Ramona Zeh
Jerzy Adamski Johannes Beckers Raf Bekeredjian Dirk H. Busch Oliver Eickelberg
Jack Favor Jochen Graw Heinz Her Christoph Hschen Hugo Katus Martin Klingenspor
Thomas Klopstock Frauke Neff Markus Ollert Holger Schulz Tobias Stger Eckhard Wolf
Wolfgang Wurst Alinder Yildirim Andreas Zimmer Martin Hrab de Angelis
Received: 11 March 2012 / Accepted: 5 July 2012 / Published online: 29 August 2012 The Author(s) 2012. This article is published with open access at Springerlink.com
Abstract Under the label of the German Mouse Clinic (GMC), a concept has been developed and implemented that allows the better understanding of human diseases on the pathophysiological and molecular level. This includes better understanding of the crosstalk between different organs, pleiotropy of genes, and the systemic impact of
envirotypes and drugs. In the GMC, experts from various elds of mouse genetics and physiology, in close collaboration with clinicians, work side by side under one roof. The GMC is an open-access platform for the scientic community by providing phenotypic analysis in bilateral collaborations (bottom-up projects) and as a partner and driver in international large-scale biology projects (top-down projects). Furthermore, technology development is
H. Fuchs and V. Gailus-Durner contributed equally to this work.
H. Fuchs V. Gailus-Durner S. Neschen T. Adler
L. C. Afonso L. Becker C. Cohrs A. Dewert B. Fridrich
W. Hans M. Horsch A. Hurt M. Kahle M. Kistler
C. Lengger T. Ludwig H. Maier S. Marschall K. Micklich
G. Mller B. Naton C. Prehn M. Ra B. Rathkolb
J. Rozman M. Scheerer E. Schiller A. Schrewe
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