Content area
Full Text
http://crossmark.crossref.org/dialog/?doi=10.1245/s10434-015-4588-y&domain=pdf
Web End = http://crossmark.crossref.org/dialog/?doi=10.1245/s10434-015-4588-y&domain=pdf
Web End = http://crossmark.crossref.org/dialog/?doi=10.1245/s10434-015-4588-y&domain=pdf
Web End = http://crossmark.crossref.org/dialog/?doi=10.1245/s10434-015-4588-y&domain=pdf
Web End = http://crossmark.crossref.org/dialog/?doi=10.1245/s10434-015-4588-y&domain=pdf
Web End = Ann Surg Oncol (2015) 22:S1475S1480 DOI 10.1245/s10434-015-4588-y
http://crossmark.crossref.org/dialog/?doi=10.1245/s10434-015-4588-y&domain=pdf
Web End = http://crossmark.crossref.org/dialog/?doi=10.1245/s10434-015-4588-y&domain=pdf
Web End = http://crossmark.crossref.org/dialog/?doi=10.1245/s10434-015-4588-y&domain=pdf
Web End = http://crossmark.crossref.org/dialog/?doi=10.1245/s10434-015-4588-y&domain=pdf
Web End = http://crossmark.crossref.org/dialog/?doi=10.1245/s10434-015-4588-y&domain=pdf
Web End = ORIGINAL ARTICLE TRANSLATIONAL RESEARCH AND BIOMARKERS
Insertion of a Stent in Obstructive Colon Cancer Can Induce a Metastatic Process in an Experimental Murine Model
Brice Malgras, MD1,2, Laura Brull, PhD3, Ra Lo Dico, MD1,2,4, Fatima El Marjou, PhD3, Sylvie Robine, PhD3, Amu Therwath, MD, PhD1,4, and Marc Pocard, MD, PhD1,2,4
1UMR INSERM 965Carcinomatosis Angiogenesis and Translational Research Lab, Lariboisire Hospital, Paris, France;
2Oncologic and Digestive Surgical Unit, Lariboisire Hospital, Paris, France; 3Unit UMR 144, Institut Curie, Paris, France; 4Universit Diderot, Paris, France
ABSTRACTBackground. Colonic self-expanding metallic stents (SEMS) are used in obstructive colorectal cancer patients as a bridge to surgery. However, its oncologic safety remains uncertain. Therefore, we attempted to clarify this further with an experimental study and constructed a mouse model of colonic cancer.
Methods. CT26 cells were injected in the rectal wall, and to mimic SEMS, a cardiac stent was inserted under endoscopy in occlusive (75 % lumen occlusion) tumors. We set up a control group (n = 22) and a stent group (n = 16), and the ndings were compared. We focused on serum lactate dehydrogenase (LDH) concentrations, circulating tumor cells, survival time, peritoneal carcinomatosis, liver metastases, and bioluminescence.
Results. One week after stent insertion, the serum LDH concentrations were signicantly higher in the stent group (506 203 IU/L) compared to the controls (229 52 IU/L) (P = 0.005). The average survival time before sacrice was signicantly lower in the stent group (15.2 1 days) compared to the controls (20 5 days) (P = 0.005). The presence of a peritoneal carcinomatosis was more frequently observed in the stent group (75 %) than in the controls
(50 %). Liver metastases were observed in 19 % of the stent group compared to the controls (4.5 %) (P = 0.29). After multivariate analysis, the stent group was still found to be associated with signicantly lower survival time (P = 0.002). Conclusions. These observations led us to conclude that in our mouse model, SEMS resulted in an increased...