The interchangeability of gabapentin 800 mg tablets: a randomized, controlled trial to establish individual bioequivalence

Abstract

For some products it is advised not to switch between medicinal products from different manufacturers once treatment started, because it is believed that they are not completely interchangeable. [...]we aimed to investigate (1) the interchangeability of gabapentin 800mg tablets marketed as Neurontin® and Gabasandoz® following FDA guidelines using the individual bioequivalence (IBE) approach and (2) the interchangeability in a more real-life situation by including two different batches of each product (Neurontin® & Gabasandoz®, both Batch 'A' and 'B').