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About the Authors:
Daniel Hasche
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing - original draft, Writing - review & editing
* E-mail: [email protected] (FR); [email protected] (DH)
Affiliation: Division of Viral Transformation Mechanisms, German Cancer Research Center (DKFZ), Heidelberg, Germany
ORCID http://orcid.org/0000-0001-9306-3059
Sonja Stephan
Roles Investigation
Affiliation: Division of Viral Transformation Mechanisms, German Cancer Research Center (DKFZ), Heidelberg, Germany
Ilona Braspenning-Wesch
Roles Investigation
Affiliation: Division of Viral Transformation Mechanisms, German Cancer Research Center (DKFZ), Heidelberg, Germany
Julita Mikulec
Roles Investigation
Affiliations Division of Viral Transformation Mechanisms, German Cancer Research Center (DKFZ), Heidelberg, Germany, Division of Virus-associated Carcinogenesis, German Cancer Research Center (DKFZ), Heidelberg, Germany
Martina Niebler
Roles Formal analysis, Visualization, Writing - original draft
Affiliation: Division of Viral Transformation Mechanisms, German Cancer Research Center (DKFZ), Heidelberg, Germany
Hermann-Josef Gröne
Roles Formal analysis, Resources
Affiliation: Division of Cellular and Molecular Pathology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Christa Flechtenmacher
Roles Formal analysis
Affiliation: Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany
Baki Akgül
Roles Formal analysis, Resources, Writing - original draft
Affiliation: Institute of Virology, University of Cologne, Cologne, Germany
Frank Rösl
Contributed equally to this work with: Frank Rösl, Sabrina E. Vinzón
Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing - original draft, Writing - review & editing
* E-mail: [email protected] (FR); [email protected] (DH)
Affiliation: Division of Viral Transformation Mechanisms, German Cancer Research Center (DKFZ), Heidelberg, Germany
Sabrina E. Vinzón
Contributed equally to this work with: Frank Rösl, Sabrina E. Vinzón
Roles Conceptualization, Formal analysis, Methodology, Project administration, Supervision, Writing - original draft
Current address: Laboratory of Molecular and Cellular Therapy, Fundación Instituto Leloir, IIBBA-CONICET, Buenos Aires, Argentina
Affiliation: Division of Viral Transformation Mechanisms, German Cancer Research Center (DKFZ), Heidelberg, Germany
ORCID http://orcid.org/0000-0002-1330-9125Abstract
Cutaneous human papillomaviruses (HPVs) are considered as cofactors for non-melanoma skin cancer (NMSC) development, especially in association with UVB. Extensively studied transgenic mouse models failed to mimic all aspects of virus-host interactions starting from primary infection to the appearance of a tumor. Using the natural model Mastomys coucha, which reflects the human situation in many aspects, we provide the first evidence that only UVB and Mastomys natalensis papillomavirus (MnPV) infection strongly promote NMSC formation. Using UVB exposures that correspond to UV indices of different geographical regions, irradiated...