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Intensive Care Med (2015) 41:11971208DOI 10.1007/s00134-015-3827-9 SEVEN-DAY PROFILE PUBLICATION
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Web End = Intravenous amino acid therapy for kidney function in critically ill patients: a randomized controlled trial
Gordon S. DoigFiona Simpson Rinaldo Bellomo Philippa T. Heighes Elizabeth A. Sweetman Douglas Chesher Carol Pollock Andrew DaviesJohn BothaPeter Harrigan Michael C. Reade
Received: 23 February 2015Accepted: 15 April 2015Published online: 30 April 2015 Springer-Verlag Berlin Heidelberg and
ESICM 2015
Take-home message: This multicenter clinical trial investigated whether an infusion of amino acids could preserve renal function during critical illness. Although the study intervention did not reduce the duration of renal dysfunction, estimated glomerular ltration rate and urine output were improved.
Electronic supplementary materialThe online version of this article (doi:http://dx.doi.org/10.1007/s00134-015-3827-9
Web End =10.1007/s00134-015-3827-9 ) contains supplementary material, which is available to authorized users.
G. S. Doig F. Simpson P. T. Heighes
E. A. SweetmanThe Northern Clinical School Intensive Care Research Unit, University of Sydney, Sydney, Australia
R. Bellomo A. Davies
School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia
D. Chesher C. Pollock
The Northern Clinical School, University of Sydney, Sydney, Australia
J. BothaFaculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia
P. HarriganJohn Hunter Hospital, Newcastle, Australia
M. C. ReadeBurns, Trauma and Critical Care Research Centre, University of Queensland, Brisbane, Australia
D. ChesherNew South Wales Health, Pathology, Newcastle, Australia
G. S. Doig ())
Intensive Care Unit, Royal North Shore Hospital, Pacic Hwy, St Leonards, NSW 2065, Australiae-mail: [email protected].: 612 9463-2633
Abstract Importance: Acute kidney injury (AKI) is characterized by severe loss of glomerular ltration rate (GFR) and is associated with a prolonged intensive care unit (ICU) stay and increased risk of death. No interventions have yet been shown to prevent AKI or preserve GFR in critically ill patients. Evidence from mammalian physiology and small clinical trials suggests higher amino acid intake may protect the kidney from ischemic insults and thus may preserve GFR during critical illness. Objective: To determine whether amino acid therapy, achieved through daily intravenous (IV) supplementation with standard amino acids, preserves kidney function...