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Four women and one man, aged 21-39 years, experienced hair loss while receiving levetiracetam 500-1000 mg/day [routes not stated] for epilepsy. Diffuse hair loss developed 3-8 weeks after starting the drug. Levetiracetam was continued at the same dosage in four patients following the onset of hair loss; their seizures were well controlled but their hair loss continued. In one patient, the dosage of levetiracetam was reduced from 1000 mg/day to 750 mg/day following the onset of hair loss; her hair loss subsequently improved but did not remit completely. In two patients, levetiracetam was eventually tapered and withdrawn after more than 1 year of treatment; their hair loss subsequently showed improvement. One patient's levetiracetam dosage was reduced from 1000 mg/day to 750 mg/day after he had been seizure free for 1 year; his hair loss subsequently showed improvement.