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Two men, aged 46 years and 31 years were described, who exhibited subtherapeutic blood levels of phenytoin following the concomitant administration of phenytoin and levofloxacin [dosages and routes not stated].
Case#1: The 46-year-old man had a history of nonconvulsive status epilepticus. He received therapy with phenytoin and valproic acid. After starting treatment, a difficulty achieving therapeutic serum levels was observed with the need to increase the dose progressively. After 11 days, he received levofloxacin...