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EDITOR-The long term intervention on fractures with tibolone (LIFT) study is a randomised trial to determine the effect of treatment with tibolone on risk of vertebral fracture in older osteoporotic postmenopausal women. The average age of the 4538 participants is 68 (SD 5.2) years. They have a bone mineral density t score at the total hip or spine ≤ - 2.5 without a fracture or a t score ≤- 2.0 with a fracture. Participants were assigned to...