Content area
Full Text
R e s e a R c h h i g h l i g h t s
L u N G C A N C E R
Expanding the range
DOI:
10.1038/nrc2220 Non-small-cell lung cancer (http://www.cancer.gov/cancertopics/types/lung
Web End =NSCLC ) includes several subtypes that, although different in histology, all have a poor prognosis. A study in Nature now shows that inactivation of the tumour-suppressor gene serine/ threonine kinase 11 (also known as http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6794&ordinalpos=2&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum
Web End =LKB1 ) underlies some of these variants, and has multiple effects on lung tumorigenesis.
Although LKB1 inactivation occurs in lung adenocarcinomas along with http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3845&ordinalpos=3&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum
Web End =KRAS activation, mouse embryonic fibroblasts lacking Lkb1
are resistant to transformationwith oncogenic Ras. To addressthis conundrum Nabeel Bardeesy, Norman Sharpless, Kwok-Kin Wong...