Abstract

Low intake of magnesium has been associated with the occurrence of lymphomas and decreased magnesium levels suppress the cytotoxic function of T cells and natural killer cells in patients with “X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia” (XMEN) syndrome. These cell types are also important mediators of immune-mediated effects after allogeneic hematopoietic stem cell transplantation. Here, we show that high posttransplant magnesium levels independently associate with a lower incidence of relapse, a higher risk of acute graft-versus-host disease, and a higher non-relapse mortality in 368 patients with acute myeloid leukemia from our center. Magnesium serum levels might impact on donor-cell-mediated immune responses in acute myeloid leukemia.

Details

Title
Magnesium levels and outcome after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia
Author
Angenendt Linus 1   VIAFID ORCID Logo  ; Hilgefort Isabel 1 ; Jan-Henrik, Mikesch 1 ; Schlüter Bernhard 2 ; Berdel, Wolfgang E 1 ; Lenz, Georg 1 ; Stelljes Matthias 1 ; Schliemann Christoph 1 

1  University Hospital Münster, Department of Medicine A, Münster, Germany (GRID:grid.16149.3b) (ISNI:0000 0004 0551 4246) 
2  University Hospital Münster, Centre for Laboratory Medicine, Münster, Germany (GRID:grid.16149.3b) (ISNI:0000 0004 0551 4246) 
Pages
1871-1878
Publication year
2021
Publication date
Jul 2021
Publisher
Springer Nature B.V.
ISSN
09395555
e-ISSN
14320584
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1007/s00277-020-04382-y
ProQuest document ID
2540003705
Copyright
© The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.