Methylphenidate augmentation during antidepressant treatment for depression in HIV: a case report

Abstract

Depression is prevalent among patients with severe or chronic illnesses. Fatigue and apathy are symptoms that are commonly encountered in such conditions. Methylphenidate as a central nervous system stimulant might present additional benefits when administered as an additional therapy for depression. We present a case report of a patient with HIV infection who had received anti-retroviral therapy to slow down the HIV virus progression and antidepressants as indicated by the diagnosis of major depressive disorder. Due to the delayed response to antidepressants, however, methylphenidate was prescribed as an additional therapy. The administration of methylphenidate helped the patient respond better especially in regard to the chronic fatigue experienced. The improvement of Hamilton Depression Rating Scale (HDRS) was also evident. During the administration of methylphenidate, antidepressants and ART were continuously provided.