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An 18-year-old boy with major depression developed manic switch and serotonin syndrome after paroxetine therapy was augmented with methylphenidate.
The boy had been receiving paroxetine 20mg augmented with methylphenidate 10mg [durations not clearly stated, and frequencies and routes of administration not stated]. After 1 month of combination therapy, he presented with a 3-day history of grandiose delusions, elated mood, decreased need for sleep, increased sexual interest...