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Three patients (2 women and 1 man), aged 65-82 years, developed corneal melt during treatment with neomycin/ polymixin-B/dexamethasone [Maxitrol]. The neomycin component of Maxitrol was thought to be responsible for altering the fine balance in the vulnerable ocular surface of these patients.
The patients had a history of sjogren's syndrome, rheumatoid arthritis and/or osteoarthritis. All the patients underwent phaco-emulsification cataract surgery, and started...
