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Neurochem Res (2012) 37:516526 DOI 10.1007/s11064-011-0638-4
ORIGINAL PAPER
Neuroprotective Effect of Sesame Seed Oil in 6-Hydroxydopamine Induced Neurotoxicity in Mice Model: Cellular, Biochemicaland Neurochemical Evidence
Saif Ahmad M. Badruzzaman Khan M. Nasrul Hoda
Kanchan Bhatia Rizwanul Haque Inayat Saleem Fazili
Arshad Jamal Jafar Salamt Khan Deepshikha Pande Katare
Received: 3 September 2011 / Revised: 12 October 2011 / Accepted: 27 October 2011 / Published online: 17 November 2011 Springer Science+Business Media, LLC 2011
Abstract Natural antioxidants have shown a remarkable reduction in oxidative stress due to excess formation of reactive oxygen species by enhancing antioxidant mechanism in the neurodegenerative disorders. Sesame seed oil (SO) is one of the most important edible oil in India as well as in Asian countries and has potent antioxidant properties thus the present study evaluated the neuroprotective effect
of SO by using 6-Hydroxydopamine (6-OHDA)-induced Parkinsons disease model in mice. The mice were fed an SO mix diet for 15 days and then 6-OHDA was injected into the right striatum of mice brain. Three weeks after 6-OHDA infusion, mice were sacriced and the striatum was removed. The neuroprotective role of SO on the activities of antioxidant and non-antioxidant enzymes such
S. Ahmad (&) I. S. Fazili A. Jamal D. P. Katare (&)
Department of Biotechnology, Jamia Hamdard (Hamdard University), New Delhi 110 062, Indiae-mail: [email protected]
D. P. Kataree-mail: [email protected]
Present Address:S. AhmadDepartment of Ophthalmology, School of Medicine, Georgia Health Sciences University (GHSU), Augusta, GA 30912, USA
M. B. Khan M. N. Hoda K. Bhatia R. Haque
Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), New Delhi 110062, India
Present Address:M. B. KhanCenter for Molecular Chaperone/Radiobiology and Cancer Virology, School of Medicine, Georgia Health Sciences University (GHSU), Augusta, GA 30912, USA
Present Address:M. N. HodaDepartment of Neurology, School of Medicine, Georgia Health Sciences University (GHSU), Augusta, GA 30912, USA
Present Address:K. BhatiaExperimental Medicine, School of Medicine, Georgia Health Sciences University (GHSU), Augusta, GA 30912, USA
Present Address:R. HaqueDepartment of Microbiology and Immunology, C6749 Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Present Address:I. S. FaziliCenter of Animal Biotechnology, Sher-i-Kashmir University of Agricultural Sciences and Technology, Shuhama (Alusteng), Srinagar 190 006, India
Present Address:A. JamalBiological Science Department, College of Science and Arts Rabigh, King...