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ABSTRACT
One of the chronic microvascular complications of type 2 diabetes is diabetic retinopathy (DR). Diabetic retinopathy is assessed through fundoscopy and one type of DR is non-proliferative. Several studies have assessed the neutrophil-lymphocyte ratio in diabetic retinopathy. This study aims to determine the neutrophil-lymphocyte ratio as a marker of non-proliferative diabetic retinopathy. Cross sectional design was applied in this study. Diagnosis of type 2 diabetes is determined based on history and laboratory examination. The research was conducted at Dr. Wahidin Sudirohusodo and Hasanuddin University Hospital in Makassar from November 2018 to April 2019. The non-proliferative DR stages are based on a fundoscopic examination. In addition, blood pressure, BMI, and HbA1C were also checked. The statistical analysis performed was descriptive statistical calculations and the frequency distribution and Anova Test. A study was conducted on 36 subjects with T2DM aged 42-78 years, with a mean of 57 ± 9 years. Mean NLR in Mild NPDR (2.20), Moderate NPDR (2.23), Severe NPDR (2.94). This shows an increase in the Mean NLR value followed by an increase in the severity of the NPDR-type DR, although it is not statistically significant (p> 0.05). It was found that the corresponding increase in the NLR value was followed by an increase in the severity of the NPDR-type DR
Keywords: Type 2 DM, Neutrophil-Lymphocyte Ratio, Diabetic Retinopathy
INTRODUCTION
Diabetes Mellitus (DM) type 2 is one of the main health problems where the incidence and prevalence are increasing worldwide, especially in people in Indonesia, especially in big cities (Qanita, 2011; Fong et al., 2004). This exponential increase in the incidence of type 2 diabetes will certainly be followed by an increase in the likelihood of chronic complications of type 2 diabetes. Various prospective studies clearly show an increase in diseases due to blockage of both microvascular blood vessels such as retinopathy, nephropathy, and neuropathy as well as macrovascular diseases such as coronary artery disease and also lower leg veins (Fong et al., 2004).
Diabetic Retinopathy (DR) is one of the chronic microvascular complications of type 2 diabetes. Diabetic retinopathy is classified into non-proliferative diabetic retinopathy and proliferative diabetic retinopathy, where non-proliferative diabetic retinopathy is an early stage of diabetic retinopathy and proliferative diabetic retinopathy is an advanced stage in diabetic retinopathy (Fong...