Content area
Full Text
Oral Maxillofac Surg (2011) 15:233237 DOI 10.1007/s10006-010-0244-7
CASE REPORT
Non-ossifying fibroma (metaphyseal fibrous defect) of the mandible
Bruno Ramos Chrcanovic & Ana Luiza Albanese & Belini Freire-Maia &
Fernanda Cardoso Fonseca Nunes & Paulo Eduardo Alencar Souza &
Ricardo Santiago Gomez
Received: 2 July 2010 /Accepted: 15 July 2010 /Published online: 28 July 2010 # Springer-Verlag 2010
Abstract A 15-year-old young man was referred for evaluation of a non-tender swelling of the left mandibular angle region. A non-ossifying fibroma was diagnosed. The lesion was enucleated under general anesthesia. The postoperative course was uneventful. There have been no signs of recurrence, and there was complete bone regeneration in the region 24 months after operation. This report also reviews other fifteen cases of non-ossifying fibroma in the mandible reported in the literature.
Keywords Non-ossifying fibroma .
Metaphyseal fibrous defect . Mandible
Introduction
Non-ossifying fibromas (NOF) are non-neoplastic lesions that occur commonly in the metaphysis of the long bones in children [1] and are extremely rare in other areas of the skeleton [2]. NOF is one of the five most frequent bone
lesions and the most common benign lesion of the skeletal system [3]. The lesion was first described by Sontag and Pyle [4] in 1941 and Jaffey and Lichtenstein [5] in 1942.
Reported fibrous bony defects of the jaws are very rare. There does appear to be some clinical differences between isolated mandibular NOF and those that occur in the long bones. In the mandibular NOF, the average age at diagnosis is greater than would be expected from the orthopedic literature [6]. In long bone lesions, there is a slight male predilection [7], whereas in the mandible, most of these lesions occurred in females [2, 6, 815]. Jaw lesions may be asymptomatic [7, 9, 11, 13, 14, 16, 17] or present with swelling [8, 10, 18].
The NOF is described histologically by the presence of numerous fibroblasts in connective tissue with variation between the giant cells, histiocytes, or foam cells present [7]. This led to several names being associated with this particular pathology [7]. The alternative names of NOF are histiocytic fibrous defect, non-osteogenic fibroma, metaphyseal fibrous defect, and cortical fibrous defect.
B. R. Chrcanovic (*)
Av. Raja Gabaglia 1000/1209 Gutierrez, Belo Horizonte MG-CEP 30441-070, Brazil...