Paracetamol/codeine/sertraline interaction: Increased codeine levels secondary to decreased metabolism of codeine into morphine: case report

A 38-year-old woman exhibited increased codeine levels secondary to decreased metabolism of codeine into morphine following concomitant administration of paracetamol/codeine [Tylenol #3] and sertraline during her pregnancy.

The woman, who delivered a preterm infant at approximately 35 weeks, had received oral paracetamol/ codeine and sertraline [dosages not stated], along with unspecified prenatal vitamins during her pregnancy (over a week before delivery). Her pregnancy...