Content area

Abstract

The human histone macroH2A.1.1 recruits activated PARP1 enzyme to chromatin through its poly(ADP-ribose)-binding macrodomain. New work shows that PARP1 and CBP can be displaced from chromatin in cancer cells that have lost macroH2A.1.1, thus leading to changes in histone H2B acetylation at cancer-relevant genes.

Details

Title
PARP1 and CBP lose their footing in cancer
Author
Timinszky, Gyula; Ladurner, Andreas G
Pages
947-8
Publication year
2014
Publication date
Nov 2014
Publisher
Nature Publishing Group
ISSN
15459993
e-ISSN
15459985
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/nsmb.2913
ProQuest document ID
1621202642
Copyright
Copyright Nature Publishing Group Nov 2014