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ABSTRACT Present study was carried out to determine the pattern of minor salivary gland tumors, diagnosed at City Medical Laboratory, Peshawar (Pakistan).
The study was conducted at Sardar Begum Dental College using the Anatomical pathology records of City Medical Laboratory, Peshawar from January 2003 to December 2012 and were analyzed by Statistical Program for Social Sciences version 16.
A total of 78 cases were diagnosed as minor salivary gland tumors. Out of these 47 were benign and 31 malignant. The male to female ratio for both benign and malignant tumors was 1:1.7. The mean age was 40.39 years. The most common benign tumor was Pleomorphic adenoma (89.3%) and malignant was Adenoid cystic carcinoma (87.09%). The hard palate was the most common affected site (57.4% in benign and 32.2% in malignant tumors).
The present study showed a different pattern of occurrence of malignant minor salivary gland tu- mors among the population of Khyber Pahktunkhwa as compared with the European and American population.
Key Words: Pleomorphic Adenoma, Adenoid Cystic Carcinoma, hard palate.
INTRODUCTION Minor salivary glands are diffusely distributed throughout the upper aero digestive tract. They are present in many sites such as hard palate, soft palate, lips, tongue, floor of the mouth, alveolar mucosa, oro- pharynx, parapharyngeal space and retro molar region.
Tumors of salivary glands are relatively uncommon and account for about 3% to 10% of neoplasms of the head and neck region.1,2,3 Tumors that originate in the minor salivary glands account for 10 to 25% of all salivary gland tumors and the most common affected site is the hard palate (40-80%).4,5,6 Most of the studies have shown that females are more affected than males.6,7,8 Salivary gland tumors are complex tumors due to their broad histological spectrum resulting from multiple tumor cell differentiation and present a challenge to the pa- thologist.9 According to the World Health Organization classification-07 salivary gland tumors are divided into 5 groups' i.e. benign epithelial tumors, malignant epithe- lial tumors, soft tissue tumors, hematolymphoid tumors and secondary tumors.10 Pleomorphic Adenoma is the most common benign tumor followed by Monomorphic Adenomas.11 Mucoepidermoid Carcinoma represented the most common malignant tumor in previous series (50%), followed by Adenoid Cystic Carcinoma (25%) and Polymorphous Low-grade Adenocarcinoma (20%). Acinic Cell Carcinomas, Adenocarcinomas and Myoep- ithelial...