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© 2019. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

The objective of this study is to investigate the chemical constituents of Suaeda monoica and Suaeda pruinosa and evaluate their effects on rat liver intoxicated by over dose of paracetamol. Qualitative analysis of (80%) methanol in water fraction revealed the presence of alkaloids, terpenoids, steroids, tannins, quinones, saponins, flavonoids and phenols from two mangrove species of S. monoica and S. pruinosa was carried out. The compounds were identified from the 80% methanol-H 2 O fraction as Rutin, quercetin, Syringic acid, Coffeic acid, Catechin, Coumaric acid, Vanillin, Gallic acid, Cinnamic acid. Amino acids analysis for the methanolic extract from the aerial parts of Suaeda monoica and Suaeda pruinosa showed the presence of thirteen amino acids and absence of valine, Isoleucine, Phenylalanine. Fatty acid analysis of lipids showed high percentage of long chain fatty acids.TLC of the lipoidal matter for each plant showed the presence β-amyrin, β-sitosterol and stigmasterol. Toxicity was stimulated by administration of a single oral dose of paracetamol (3 g/kg body weight). The extract of the aerial parts of plants (100 mg/kg) was utilized on a pre-and post-treatment basis. Both extracts significantly improved liver and kidney function with prophylactic or therapeutic treatments. Histopathological and histochemical studies showed parallel effects with the biochemical measured parameters.

Details

Title
Phytoconstituents and Hepatoprotective Effect of Suaeda Monoica Forssk and Suaeda Pruinosa Lange
Author
Elsharabasy, F S; Metwally, N S; Mahmoud, A H; Soliman, M S; Youness, E R; Farrag, A H
Pages
117-129
Publication year
2019
Publication date
2019
Publisher
Biomedical and Pharmacology Journal
ISSN
09746242
e-ISSN
24562610
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2264179922
Copyright
© 2019. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.