Piericidins C7 and C8, New Cytotoxic Antibiotics Produced by a Marine Streptomyces sp.

Abstract

Piericidins C₇ and C₈ , two new members of the piericidin family, were isolated from a marine actinomycete. The producing organism was identified as Streptomyces sp. based on the cultural, biochemical and chemotaxonomical characteristics as well as the 16S rRNA sequence. Piericidins C ₇ and C₈ showed selective cytotoxicity against rat glia cells transformed with the adenovirus E1A gene (IC₅₀ C₇ : 1.5 nM, C₈ : 0.45 nM) and Neuro-2a mouse neuroblastoma cells (IC₅₀ C₇ : 0.83 nM, C₈ : 0.21 nM).