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Abstract
In pragmatic trials, participants are broadly representative of people who will receive a treatment or diagnostic strategy, and the outcomes affect day-to-day care. The authors review the unique features of pragmatic trials through a wide-ranging series of exemplar trials.
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1 From the Robertson Centre for Biostatistics, University of Glasgow, Glasgow (I.F.), and the Centre for Healthcare Randomised Trials, Health Services Research Unit, University of Aberdeen, Aberdeen (J.N.) — both in the United Kingdom.