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Rx
For 100 mL
Prednisolone sodium phosphate 1 g
Methylparaben 65 mg
Propylparaben 35 mg
Orange syrup 40 mL
Purified water qs 100 mL
METHOD OF PREPARATION
1. Calculate the required quantity of each ingredient for the total amount to be prepared.
2. Weigh and/or measure each ingredient accurately.
3. Add the methylparaben and propylparaben to about 50 mL of previously heated purified water and mix until dissolved.
4. Cool the solution, add the prednisolone sodium phosphate and orange syrup, and mix well.
5. Add purified water to volume and mix well.
6. Package and label.
PACKAGING
Package in tight, light-resistant containers.1
LABELING
Keep out of reach of children. Use only as directed. Shake well.
STABILITY
Abeyond-use date of 6 months can be used for this preparation.1,2
USE
Prednisolone is an adrenocorticosteroid.
QUALITY CONTROL
Quality-control assessment can include weight/volume, pH, specific gravity, active drug assay, color, rheological properties/pourability, physical observation, and physical stability (discoloration, foreign materials, gas formation, mold growth).3
DISCUSSION
Prednisolone sodium phosphate (C^sub 21^H^sub 27^Na^sub 2^O^sub 8^P, MW484.39) occurs as a white or slightly yellow, friable granules or powder that is odorless or has a slight odor. It is slightly...