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Congenital scoliosis is caused by anomaly in formation or segmentation of vertebral elements, and ranges from benign scoliosis to malformations causing severe deformity. The component of the disease is attributed to abnormal development of the vertebrae during 4-6 weeks of gestation. It can be associated with a number of syndromic and nonsyndromic disorders (1,2). We report the first case of prenatal diagnosis of fetal scoliosis with Down syndrome.
The mother, a 36-years-old, gravida 4, parité 2 was referred to our hospital with an abnormal triple-test at 18 weeks of gestation, with a final biochemical risk for Down's syndrome more than 1:50. The family history was unremarkable and the parents were unrelated. A detailed ultrasound scan of the fetus revealed a single fetus with biparietal diameter of 42 mm, head circumference of 147 mm, femur length of 25 mm and abdominal circumference of 128 mm. Also the nuchal fold thickness and the nasal bone...