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In the present work, we have formulated the oral tablets of paracetamol by using Aegle marmelos fruit gum as a binder. The four different tablet formulations were prepared by wet granulation method. The binder concentrations used in the formulation were 2, 4, 6 & 8 % w/w of cordia fruit gum; tablets were subjected for evaluation of hardness, friability, drug content uniformity. Preliminary evaluation of granules showed that, 0.71 to 0.77 mm granule size, 29.20 to 30.10° angles of repose and 22.1 to 12.7 % fines. Hardness was found to be in the range of 7.1 to 7.4 kg/cm^sup 2^, the percent friability was in the range of 1.50 to 0.75 %, and tablet showed 97.46 to 98.96 % of labeled amount of paracetamol indicating uniformity in drug content, 8 to 18 min disintegration time and more than 90% dissolution in 75 min. Tablets at 6 % w/w binder concentration showed more optimum results as tablet binder. The Aegle marmelos gum was found to be useful for the preparation of uncoated tablet dosage form.
INTRODUCTION
Gum is obtained from fruits of Aegle marmelos belonging to family Rutaceae is indigenous to India. This tree is generally found in the outer Himalayas, Shivaliks and South Indian plateau with altitudes ranging from 250 to 1200 m. It prefers comparatively drier and sunny or warmer aspect of the hill slopes with well-drained loamy soil. It is found growing naturally in dry temperate region. Its natural habitat begins from Burma and extends to Afghanistan, and also the Deccan plateau. The ripen fruit pulp is red in colour with mucilaginous and astringent taste. The pulp contains carbohydrates, proteins, vitamin C, vitamin A, angelenine, marmeline, dictamine, O-methyl fordinol and isopentyl halfordinol. The neutral oligosaccharides were characterized as 3-0-beta-D-galactopyranosyl-L-arabinose, 5-0-beta-D-galactopyranosyl-L-arabinose, and 3-0-beta-D-galactopyranosyl-D-galactose, and the acidic oligosaccharides (Bhattacharya and Mukherjee., 1976). The plant extracts were used against multi-drug resistant Salmonella typhi(Vh\Aan et dl., 2004). During summer bael gives a very cool and cozy shade. It also improves the environment by utilizing carbon dioxide and exhaling oxygen. The screening was done of some plants of importance in the Ayurvedic system of...