Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial

Abstract

Type 2 diabetes affects almost one in ten adults in the UK, and 422 million adults worldwide.1,2 Most people with type 2 diabetes have disease-related morbidity and reduced longevity. The disease is particularly devastating for the growing numbers of younger people affected, who tend to be more obese and lose more life-years through diabetes.3 Current guidelines for management of type 2 diabetes focus heavily on multiple drug treatments to reduce blood glucose and the associated elevated risks of cardiovascular disease, but life expectancy remains substantially reduced.