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Abstract
Neurodegenerative diseases are a growing burden, and there is an urgent need for better biomarkers for diagnosis, prognosis, and treatment efficacy. Structural and functional brain alterations are reflected in the protein composition of cerebrospinal fluid (
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1 Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany
2 Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany; NNF Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
3 Departments of Nutrition & Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
4 Institute of Clinical Chemistry, Faculty of Medicine, Kiel University, Kiel, Germany; Department of Neurology, Faculty of Medicine, Kiel University, Kiel, Germany
5 Department of Neurology, Medical Faculty, Otto von Guericke University Magdeburg, Magdeburg, Germany; Department of Neurology, Charité Universitätsmedizin Berlin, Berlin, Germany
6 Department of Neurology, Medical Faculty, Otto von Guericke University Magdeburg, Magdeburg, Germany
7 Experimental & Clinical Research Center (ECRC), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt‐Universität zu Berlin, & Berlin Institute of Health, Berlin, Germany
8 Department of Psychiatry, corporate member of Freie Universität Berlin, Humboldt‐Universität zu Berlin & Berlin Institute of Health, Charité Universitätsmedizin Berlin, Berlin, Germany
9 Department of Psychiatry, corporate member of Freie Universität Berlin, Humboldt‐Universität zu Berlin & Berlin Institute of Health, Charité Universitätsmedizin Berlin, Berlin, Germany; German Center for Neurodegenerative Diseases, Berlin, Germany
10 Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland
11 German Center for Neurodegenerative Diseases (DZNE), Munich, Germany; Munich Cluster for Systems Neurology, Munich, Germany
12 Departments of Nutrition & Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Public Health, University of Copenhagen, Copenhagen, Denmark
13 Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; UK Dementia Research Institute at UCL, London, UK; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK