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Canada - The potential association between proton pump inhibitor (PPI) treatment and hypomagnesemia has been suggested in the literature and communicated by other regulatory authorities (1-8). Recent studies have suggested that hypomagnesemia can be induced by several if not all PPIs (1 ,2,4,6).
The mechanism by which PPIs induce hypomagnesemia is unclear. It may involve defects in magnesium absorption in the small intestine by affecting the function of the transient receptor potential melastin 6 (TRPM6) channel (1,2,6). Effects on magnesium absorption have not been reported with short-term use of PPIs. Published case reports suggest that PPI-induced hypomagnesemia occurs after prolonged use (^ 1 year) (1-6). Magnesium is involved in bone metabolism. Its deficiency may induce parathyroid dysfunction and hypoparathyroidism, thereby affecting the regulation of calcium levels (9-11). Hypomagnesemia may also trigger hypokalemia via activation of...