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Eur Radiol (2012) 22:642653 DOI 10.1007/s00330-011-2302-4
CONTRAST MEDIA
Quantifying differences in hepatic uptake of the liver specific contrast agents Gd-EOB-DTPA and Gd-BOPTA: a pilot study
O. Dahlqvist Leinhard & N. Dahlstrm & J. Kihlberg &
P. Sandstrm & T. B. Brismar & . Smedby & P. Lundberg
Received: 5 April 2011 /Revised: 12 September 2011 /Accepted: 18 September 2011 /Published online: 9 October 2011 # European Society of Radiology 2011
AbstractObjectives To develop and evaluate a procedure for quantifying the hepatocyte-specific uptake of Gd-BOPTA and Gd-EOB-DTPA using dynamic contrast-enhanced (DCE) MRI.
Methods Ten healthy volunteers were prospectively recruited and 21 patients with suspected hepatobiliary disease were retrospectively evaluated. All subjects were examined with DCE-MRI using 0.025 mmol/kg of Gd-EOB-DTPA. The healthy volunteers underwent an additional examination using0.05 mmol/kg of Gd-BOPTA. The signal intensities (SI) of liver and spleen parenchyma were obtained from unenhanced and enhanced acquisitions. Using pharmacokinetic models of the liver and spleen, and an SI rescaling procedure, a hepatic uptake rate, KHep, estimate was derived. The KHep values for
Gd-EOB-DTPA were then studied in relation to those for Gd-BOPTA and to a clinical classification of the patients hepatobiliary dysfunction.
Results KHep estimated using Gd-EOB-DTPA showed a significant Pearson correlation with KHep estimated using Gd-BOPTA (r=0.64; P<0.05) in healthy subjects. Patients with impaired hepatobiliary function had significantly lower KHep than patients with normal hepatobiliary function (KHep=0.090.05 min-1 versus KHep=0.240.10 min1;
P<0.01).
Conclusions A new procedure for quantifying the hepatocyte-specific uptake of T1-enhancing contrast agent was demonstrated and used to show that impaired hepatobiliary function severely influences the hepatic uptake of Gd-EOB-DTPA.
O. Dahlqvist Leinhard : N. Dahlstrm (*) : J. Kihlberg :
. Smedby : P. LundbergCenter for Medical Image Science and Visualization (CMIV), Linkping University,SE-58185 Linkping, Swedene-mail: [email protected]
N. Dahlstrm : J. Kihlberg : . Smedby : P. Lundberg Depts of Radiology, Linkping University and Radiology, UHL County Council of stergtland,Linkping, Sweden
O. Dahlqvist Leinhard : P. LundbergDepts of Radiation Physics,Linkping University and Radiation Physics, UHL County Council of stergtland, Linkping, Sweden
T. B. BrismarDepartment of Clinical Science, Intervention and Technology at Karolinska Institutet, Division of Medical Imaging and Technology, Karolinska University Hospital in Huddinge, Stockholm, Sweden
T. B. BrismarDepartment of Radiology,Karolinska University Hospital in Huddinge, Stockholm, Sweden
P. SandstrmDivision of Surgery and...