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Xiaowei Cao [1; 2; 3; 4] and Min Bao [1; 2] and Yibo Shan [1; 2] and Wei Li [1; 2] and Hongcan Shi [1; 2; 5]

Academic Editor: Krishna Kant

1, Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225001, China, yzu.edu.cn

2, Department of Integrative Traditional & Western Medicine, Medical College, Yangzhou University, Yangzhou 225001, China, yzu.edu.cn

3, Jiangsu Coinnovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, China, yzu.edu.cn

4, Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou 225009, China, yzu.edu.cn

5, Jiangsu Key Laboratory of Experimental & Translational Noncoding RNA Research, Medical College, Yangzhou University, Yangzhou 225001, China, yzu.edu.cn

Received Jun 18, 2017; Accepted Aug 30, 2017

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

1. Introduction

MicroRNAs (miRNAs) are small (19–25 nucleotides), noncoding, regulatory RNAs that play critical regulatory roles in almost every biological processes [1, 2]. Some studies concluded that approximately one-third to one-half of human genes are directly regulated by miRNAs with each miRNA predicted to target several hundred transcripts, making miRNAs one of the largest families of gene regulators [3]. miRNAs are implicated in the regulation of various cellular processes, including proliferation, metastasis, differentiation, and apoptosis [4]. The accumulating evidence has shown that miRNAs or patterns of miRNAs expressed may serve as biomarkers for a number of diseases and genetic disorders, particularly in the development of cancers [5, 6]. For example, Huo et al. found that miR-10a-5p have good predictive value in assessing the 28-day mortality of patients with sepsis [7]. Zhi et al. reported that miR-10a-5p may serve as a biomarker useful to improving the management of acute myeloid leukemia patients [8]. The similar results were reported in the cervical cancer [9, 10]. Zhong et al. found that miR-125a-5p inhibited the proliferation and invasion of lung cancer cells and facilitated lung cancer cell apoptosis [11]. Moreover miR-125a-5p expression was found to be associated with the age of breast cancer patients [12]. Li et al. reported that overexpression of miR-196a-5p is associated with lymph node metastasis and clinical stage in gastric cancer [13]. The expression pattern...

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