Rational dosing of gabapentin and pregabalin in chronic kidney disease

Abstract

Introduction

Renal dose adjustments for gabapentin and pregabalin are ubiquitously evident in the medical literature. All manufacturers for these branded and generic dosage forms list dosing recommendations relative to creatinine clearance (CrCl) for both medications (Table 1).^1,2 However, the basis of these recommendations has not been well articulated.