It appears you don't have support to open PDFs in this web browser. To view this file, Open with your PDF reader
Abstract
REM sleep without atonia (RSWA) is a key feature for the diagnosis of rapid eye movement (REM) sleep behaviour disorder (RBD). We introduce RBDtector, a novel open-source software to score RSWA according to established SINBAR visual scoring criteria. We assessed muscle activity of the mentalis, flexor digitorum superficialis (FDS), and anterior tibialis (AT) muscles. RSWA was scored manually as tonic, phasic, and any activity by human scorers as well as using RBDtector in 20 subjects. Subsequently, 174 subjects (72 without RBD and 102 with RBD) were analysed with RBDtector to show the algorithm’s applicability. We additionally compared RBDtector estimates to a previously published dataset. RBDtector showed robust conformity with human scorings. The highest congruency was achieved for phasic and any activity of the FDS. Combining mentalis any and FDS any, RBDtector identified RBD subjects with 100% specificity and 96% sensitivity applying a cut-off of 20.6%. Comparable performance was obtained without manual artefact removal. RBD subjects also showed muscle bouts of higher amplitude and longer duration. RBDtector provides estimates of tonic, phasic, and any activity comparable to human scorings. RBDtector, which is freely available, can help identify RBD subjects and provides reliable RSWA metrics.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details
1 Forschungszentrum Jülich, Institute of Neuroscience and Medicine (INM-1), Jülich, Germany (GRID:grid.8385.6) (ISNI:0000 0001 2297 375X)
2 Medical University of Innsbruck, Department of Neurology, Innsbruck, Austria (GRID:grid.5361.1) (ISNI:0000 0000 8853 2677)
3 University Hospital Cologne, University of Cologne, Department of Neurology, Faculty of Medicine, Cologne, Germany (GRID:grid.411097.a) (ISNI:0000 0000 8852 305X); Forschungszentrum Jülich, Institute of Neuroscience and Medicine (INM-3), Jülich, Germany (GRID:grid.8385.6) (ISNI:0000 0001 2297 375X)
4 Aarhus University Hospital, Department of Nuclear Medicine and PET Centre, Aarhus, Denmark (GRID:grid.154185.c) (ISNI:0000 0004 0512 597X); Aarhus University Hospital, Department of Neurology, Aarhus, Denmark (GRID:grid.154185.c) (ISNI:0000 0004 0512 597X); Aarhus University, Department of Clinical Medicine, Aarhus, Denmark (GRID:grid.7048.b) (ISNI:0000 0001 1956 2722)
5 University Hospital Cologne, University of Cologne, Department of Neurology, Faculty of Medicine, Cologne, Germany (GRID:grid.411097.a) (ISNI:0000 0000 8852 305X)
6 FH Aachen University of Applied Sciences, Department of Medical Engineering and Technomathematics, Jülich, Germany (GRID:grid.434081.a) (ISNI:0000 0001 0698 0538); FH Aachen University of Applied Sciences, Institute for Data-Driven Technologies, Jülich, Germany (GRID:grid.434081.a) (ISNI:0000 0001 0698 0538)
7 Aarhus University Hospital, Department of Nuclear Medicine and PET Centre, Aarhus, Denmark (GRID:grid.154185.c) (ISNI:0000 0004 0512 597X)
8 University Hospital Cologne, University of Cologne, Department of Neurology, Faculty of Medicine, Cologne, Germany (GRID:grid.411097.a) (ISNI:0000 0000 8852 305X); Forschungszentrum Jülich, Institute of Neuroscience and Medicine (INM-3), Jülich, Germany (GRID:grid.8385.6) (ISNI:0000 0001 2297 375X); Aarhus University Hospital, Department of Nuclear Medicine and PET Centre, Aarhus, Denmark (GRID:grid.154185.c) (ISNI:0000 0004 0512 597X)