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Graefes Arch Clin Exp Ophthalmol (2008) 246:345352 DOI 10.1007/s00417-007-0658-6
RETINAL DISORDERS
Reduction of iatrogenic RPE lesions in AMD patients: evidence for wound healing?
Doris Rabenlehner & Boris V. Stanzel & Ilse Krebs &
Susanne Binder & Alexandra Goll
Received: 8 March 2007 / Revised: 28 June 2007 / Accepted: 8 July 2007 / Published online: 18 August 2007 # Springer-Verlag 2007
Abstract Purpose Our purpose was to study retinal pigment epithelium (RPE) wound healing in patients with age-related macular degeneration (AMD). Patients and methods Abrasive debridement of nasal RPE was performed with a metal cannula during pars plana vitrectomy for foveal choroidal neovascularization (CNV) membrane excision combined with simultaneous autologous RPE transplantation. Fundus autofluorescence, fluo-
Presented in part at the annual meeting of the Association for Research in Vision and Ophthalmology, Fort Lauderdale, FL, USA, 2529 April 2004.
Supported by unrestricted research grant from the L. Boltzmann Institute to SB.
D. Rabenlehner : B. V. Stanzel : I. Krebs : S. Binder The Ludwig Boltzmann Institute for Retinology and Biomicroscopic Lasersurgery,Vienna, Austria
D. Rabenlehner : I. Krebs : S. Binder Department of Ophthalmology, Rudolph Foundation Clinic, Vienna, Austria
B. V. Stanzel Department of Ophthalmology, Stanford University School of Medicine, Stanford, CA, USA
A. GollMedical Statistics Institute, Medical University of Vienna, Vienna, Austria
D. Rabenlehner (*)
Boltzmann Institute for Retinology and Biomicroscopic Laser Surgery, Juchgasse 25,1030 Vienna, Austriae-mail: [email protected]
rescein angiography images, and red-free pictures were taken initially within 12 weeks postoperatively, subsequently in 2-week intervals until 3 months, monthly until 6 months, and every 3 months thereafter. The borders of these lesions were measured; areas were calculated and compared using ArchiCad Software. Fourteen eyes of 14 patients suffering from AMD were included (nine women and four men, mean age 75.6 years 6.6 years). Results Six of 14 (42.9 %) patients showed a reduction of the RPE debrided area. The size of these lesions reduced5.620% within 2 postoperative months compared with their size at first examination (from a mean of 13.7 mm2 7.2 at baseline to a mean of 12.8 mm2 6.7 at 2 months postoperatively). No further reduction of the lesions was seen after the 2 months. In eight cases, borders of the RPE debrided areas stayed stable during observation time. Conclusions Wound healing of...