Regulators to the rescue

Abstract

Saligrama and colleagues now report their investigation into whether a similarly coordinated T-cell response might be detected in experimental autoimmune encephalomyelitis (EAE), which is a mouse model of multiple sclerosis. [...]Saligrama et al. observed coordinated mobilization of CD4 and CD8 T cells in people with recent-onset multiple sclerosis, suggesting that their findings in mice might also apply to humans. The identification of cell-surface markers that could be used to reliably isolate putative human CD8 regulatory T cells should offer insight into whether such cells contribute to human autoimmune disease. [...]defining the antigens that such cells recognize could pave the way to new clinical treatments.