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Clin Rheumatol (2015) 34:12591263
DOI 10.1007/s10067-014-2632-0
ORIGINAL ARTICLE
The relationship between disease activity and depression and sleep quality in Behets disease patients
Irfan Koca & Esen Savas & Zeynel Abidin Ozturk &
Ahmet Tutoglu & Ahmet Boyaci & Samet Alkan &
Bnyamin Kisacik & Ahmet Mesut Onat
Received: 6 February 2014 /Revised: 4 April 2014 /Accepted: 4 April 2014 /Published online: 10 May 2014 # Clinical Rheumatology 2014
Abstract Like many chronic illnesses, Behets disease (BD) has been reported to negatively affect the quality of life and mental health of the individuals diagnosed with this disease. This study aims to investigate the relationship between disease activity and depression and sleep quality in BD. Forty patients with BD and 30 healthy subjects (controls), aged 1865, were included in this study, and all of the subjects enrolled in this study were assessed in terms of depression and sleep quality using the Beck depression index (BDI) and Pittsburg sleep quality index (PSQI). Additionally, the subjects with BD were also assessed using the Behets disease current activity form (BDCAF). It was determined that the depression and sleep quality scores were significantly higher in the BD group compared to those in the control group (p=0.012 and p=0.020, respectively), and in the BD group, significant positive correlations were determined between the BDCAF and
depression and sleep quality scores (r=0.559, p<0.001 and r=0.462, p=0.003, respectively). We believe that the assessment of BD patients for depressive symptoms and sleep quality, and providing medical support to those who need it, will contribute to the treatment and follow-up processes of BD.
Keywords Behets disease . Behets disease activity index . Depression . Sleep quality
Introduction
Behets disease (BD) is a systemic, vasculitic disease without known etiology, defined by a classic triad consisting of inflammation of the eyes, oral, and genital ulcers [1]. Vasculitis and perivascular inflammation are responsible for the pathology of the lesions of the disease; although genetic predisposition, autoimmunity, and viral and bacterial infections are blamed for the etiology of BD. Additionally, physical and psychological stresses have been suggested in the development of autoimmune disease, since numerous animal and human studies have demonstrated the effects of stressors on immune function. Also, several researches have reported that there is a stress factor in most...